Alkaline phosphatase
S-AFOS KL 1046
Most of the alkaline phosphatase in serum (S-AFOS) in adults is usually liver-derived, but bone-derived enzyme is found as well. Serum alkaline phosphatase is elevated in e.g. Paget’s disease, rickets and bone metastases as well as hyperparathyroidism. Elevated values can also be seen in patients with bile duct obstruction.
Indications
Diagnostics and monitoring of hepatic, biliary and bone diseases. Diagnostics of increased osteoblast activity.
Sample
1.0 mL of serum (min. 0.5 mL) or Li-heparin plasma. Haemolysis interferes with the assay.
Storage and delivery
Delivery at room temperature, if it arrives within 24 hours. Haemolysis interferes with the assay.
Method
Photometric, in accordance with IFCC recommendation.
Turnaround time
1-2 weekdays
Reference ranges
| Age (years) | Girls/Adults | Boys/Adults | Unit |
|---|---|---|---|
| 1 – 5 | 115 – 390 | 115 – 390 | U/L |
| 6 – 7 | 115 – 460 | 115 – 460 | U/L |
| 8 – 9 | 115 – 345 | 115 – 345 | U/L |
| 10 – 11 | 115 – 435 | 115 – 335 | U/L |
| 12 – 13 | 90 – 335 | 125 – 405 | U/L |
| 14 – 15 | 80 – 210 | 80 – 445 | U/L |
| 16 – 18 | 35 – 125 | 55 – 330 | U/L |
| over 18 | 35 – 105 | 35 – 105 | U/L |
Inquiries
martin.tornudd@milalab.fi
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