CHOLESTEROL, LDL, oxidised
P-Ox-LDL ATK 8053
When considering the progression of arteriosclerosis, the most detrimental elements are referred to as small, dense LDL particles. These particles have the ability to easily traverse the blood vessel wall and enter the innermost layer of the endothelium known as the intima. These particular particles are also more prone to undergoing oxidation. Their buildup within the intima triggers an inflammatory response, resulting in the accumulation of inflammatory cells called monocytes.
The transformation of monocytes into macrophages subsequently enhances the oxidation of LDL particles, causing the collection of oxidized LDL particles within macrophages via specific receptors known as ”through waste receptors.” As the volume of oxidized LDL escalates, cholesterol fills the macrophages, ultimately catalyzing the transition of macrophages into foam cells. This progression instigates chronic inflammation and the accumulation of cholesterol within the vessel wall.
The oxidation of LDL particles, the gathering of cholesterol within macrophages, and the formation of foam cells represent pivotal stages in the advancement of atherosclerosis.
Indications
Assessment of risk for cardiovascular diseases, development of atherosclerosis and metabolic syndrome.
Preparation
Blood sample. Normal eating and drinking is allowed prior to sampling.
Sample
1 mL of EDTA or lithium heparin plasma or serum
Storage and delivery
Delivery at room temperature on the sampling day. Room temperature storage should be avoided. If shipping on the day of sampling is not possible, store frozen.
Method
ELISA
Turnaround time
10 – 15 weekdays
Reference ranges
Coronary artery disease risk assessment
< 45 U/L low risk (recommended value)
45 – 59 U/L moderate risk
60 – 79 U/L high risk
> 79 U/L very high risk
The values are based on the declaration of the method manufacturer.
Interpretation of results
Patients experiencing chest pain, those who have suffered myocardial infarctions, individuals with subclinical atherosclerosis but no symptoms, and those with confirmed atherosclerosis all exhibit notably elevated levels of oxidized LDL. Additionally, increased concentrations of oxidized LDL are observed in cases of metabolic syndrome, obesity, impaired sugar tolerance, diabetes, and untreated hypothyroidism.
Adopting a plant-based diet, engaging in dietary measures, maintaining proper sugar equilibrium, and ceasing smoking all contribute to reducing the concentration of oxidized LDL cholesterol.
Inquiries
martin.tornudd@milalab.fi
Page updated 24.8.2023
